Explored by Columbus in 1502 and by Balboa in 1513, Panama was the principal shipping point to and from South and Central America in colonial days. In 1821, when Central America revolted against Spain, Panama joined Colombia, which had already declared its independence. For the next 82 years, Panama attempted unsuccessfully to break away from Colombia. Between 1850 and 1900 Panama had 40 administrations, 50 riots, 5 attempted secessions, and 13 U.S. interventions. After a U.S. proposal for canal rights over the narrow isthmus was rejected by Colombia, Panama proclaimed its independence with U.S. backing in 1903.

For canal rights in perpetuity, the U.S. paid Panama $10 million and agreed to pay $250,000 each year, which was increased to $430,000 in 1933 and to $1,930,000 in 1955. In exchange, the U.S. got the Canal Zone—a 10-mile-wide strip across the isthmus—and considerable influence in Panama’s affairs. On Sept. 7, 1977, Gen. Omar Torrijos Herrera and President Jimmy Carter signed treaties giving Panama gradual control of the canal, phasing out U.S. military bases, and guaranteeing the canal’s neutrality.

Nicolas Ardito Barletta, Panama’s first directly elected president in 16 years, was inaugurated on Oct. 11, 1984, for a five-year term. He was a puppet of strongman Gen. Manuel Noriega, a former CIA operative and head of the secret police. Noriega replaced Barletta with vice president Eric Arturo Delvalle a year later. In 1988, Noriega was indicted in the U.S. for drug trafficking, but when Delvalle attempted to fire him, Noriega forced the national assembly to replace Delvalle with Manuel Solis Palma. In Dec. 1989, the assembly named Noriega “maximum leader” and declared the U.S. andPanama to be in a state of war. In Dec. 1989, 24,000 U.S. troops seized control of Panama City in an attempt to capture Noriega after a U.S. soldier was killed in Panama. On Jan. 3, 1990, Noriega surrendered himself to U.S. custody and was transported to Miami, where he was later convicted of drug trafficking. Guillermo Endara, who probably would have won an election suppressed earlier by Noriega, was installed as president.

Defying the current Latin American trend for left-leaning governments, Panama elected millionaire businessman Ricardo Martinelli as its president on May 3, 2009. After a period of rapid economic growth, Panama had succumbed to the global recession. Trading on his personal record of success—and utilizing his fortune to get his message out—Martinelli promised to encourage foreign investment and help the poor.